An Efficient Synthesis of Novel Dextran-Arsenite Nanoparticles intended for Potential Antitumor Drug Material

نویسندگان

چکیده

The functionalization of polysaccharides with synthetic nanopolymers has attracted great attention owing to the applications this method in many industrial fields. This work aimed investigate effect arsenic trioxide on dextran. Dextran-arsenite nanoparticle formation was induced by microwave sulfuric acid as a catalyst. Various analytical techniques were used verify structure nanopolymers. Besides, various reaction conditions, such dextran concentration, concentration and pH, investigated determine their impact particle size. results indicated that product an arsenite-based nanomaterial retaining basic configuration size positively correlated pH but negatively concentration. Moreover, inhibitory effects dextran-arsenite nanoparticles growth human colorectal cancer cell line HCT-116 hepatoma carcinoma lines Huh-7 SMMC-7721 studied. showed could inhibit proliferation these three tumor dose-dependent manner. Therefore, be new type functional for further study synthesis, biological activity development polysaccharide drugs.

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ژورنال

عنوان ژورنال: Anais Da Academia Brasileira De Ciencias

سال: 2021

ISSN: ['0001-3765', '1678-2690']

DOI: https://doi.org/10.1590/0001-3765202120190551